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[주요 연구 분야 1] 세포 배양 기술 개발
Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells. Stem Cells Dev. 2013.
Nanotopographical control for maintaining undifferentiated human embryonic stem cell colonies in feeder free conditions. Biomaterials. 2014.
Selective elimination of culture-adapted human embryonic stem cells with BH3 mimetics. Stem Cell Reports. 2018.
Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix. Biomaterials. 2018.
In silico design and fabrication of an SFI chip-based microspheroid culture system. Biomater Sci. 2022.
[주요 연구 분야 2] 세포 분화 기술 개발
Assessment of differentiation aspects by the morphological classification of embryoid bodies derived from human ESC. Stem Cells Dev. 2011.
Optimizing hESCs differentiation efficiency by screening size-tunable homogenous embryoid bodies. Biomaterials. 2014.
Optimal Production of 3D Neuronal Lineage Population by Morphological Classification. Tissue Eng Regen Med. 2025.
[주요 연구 분야 3] 혈관내피세포 및 심근세포 생산 기술 개발
Effective isolation and culture of endothelial cells in embryoid body differentiated from human embryonic stem cells. Stem Cells Dev. 2007.
Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells. Int J Cardiol. 2013.
Functional equivalency in human SCNT-ES - endothelial cells. Stem Cells. 2019.
Electrically stimulable indium tin oxide plate for long-term in vitro cardiomyocyte culture. Biomater Res. 2020.
CD47-mediated purification of human ventricular cardiomyocytes derived from pluripotent stem cells. Animal Cells and Systems. 2026.
[주요 연구 분야 4] 혈관 질환 치료제 개발을 위한 전임상 연구
Improvement of postnatal neovascularization by hESC-derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation. 2007. (BRIC 한빛사 논문)
A comparison of human cord blood- and embryonic stem cell-derived endothelial progenitor cells in the treatment of chronic wounds. Biomaterials. 2013.
Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity. Stem Cell Reports. 2015.
Examination of endothelial cell-induced epidermal regeneration in a mice-based chimney wound model. Wound Repair Regen. 2016.
Predicting in vivo therapeutic efficacy of bioorthogonally labeled EPCs in hind limb ischemia models via non-invasive fluorescence molecular tomography. Biomaterials. 2021. (BRIC 한빛사 논문)
[주요 연구 분야 5] 심장 질환 치료제 개발을 위한 전임상 연구
The use of aggregates of purified cardiomyocytes derived from human ESCs for functional engraftment after myocardial infarction. Biomaterials. 2013
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. Nat Commun. 2019. (BRIC 한빛사 논문)
Enhancement strategy for effective vascular regeneration through dual stem cell approach following myocardial infarction. Exp Mol Med. 2022. (BRIC 한빛사 논문)
Effect and application of cryopreserved 3D microcardiac spheroids in myocardial infarction therapy. Clin Transl Med. 2022. (BRIC 한빛사 논문)
[주요 연구 분야 6] 면역인간화 마우스를 이용한 전임상 연구
[주요 연구 분야 7] 심근 세포를 이용한 독성 평가 연구
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes. Antiviral Res. 2020.
A machine learning platform for genotype-specific cardiotoxicity risk prediction using patient-derived iPSC-CMs. J Adv Res. 2025. (BRIC 한빛사 논문)
Stage-specific cardiotoxicity induced by bisphenol A using human pluripotent stem cell-derived 2D- and 3D-cardiomyocyte models. J Tissue Eng. 2025.
Toward animal-free cardiac safety testing: Early detection of cardiotoxic reactions via multimodal in vitro readouts. J Adv Res. 2026. (BRIC 한빛사 논문)
