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[주요 연구 분야 1] 세포 배양 기술 개발
Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells. Stem Cells Dev. 2013.
Nanotopographical control for maintaining undifferentiated human embryonic stem cell colonies in feeder free conditions. Biomaterials. 2014
Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix, Biomaterials. 2018.
Selective elimination of culture-adapted human embryonic stem cells with BH3 mimetics. Stem Cell Reports. 2018
[주요 연구 분야 2] 세포 분화 기술 개발
Effective isolation and culture of endothelial cells in embryoid body differentiated from human embryonic stem cells. Stem Cells Dev. 2007.
Assessment of differentiation aspects by the morphological classification of embryoid bodies derived from human ESC. Stem Cells Dev. 2011.
Optimizing hESCs differentiation efficiency by screening size-tunable homogenous embryoid bodies. Biomaterials. 2014.
[주요 연구 분야 3] 심혈관세포 생산 기술 개발
Improvement of neovascularization by hESC - endothelial cells transplantation in a mouse hindlimb ischemia. Circulation. 2007.
Repair of ischemic injury by iPSC – endothelial cells without teratoma through selective photosensitivity. Stem Cell Reports. 2015.
Functional equivalency in human SCNT-ES - endothelial cells. Stem Cells. 2019.
Electrically stimulable indium tin oxide plate for long-term in vitro cardiomyocyte culture. Biomater Res. 2020.
Effect and application of cryopreserved three-dimensional microcardiac spheroids in myocardial infarction therapy. Clin Transl Med. 2022.
[주요 연구 분야 4] 혈관 질환 세포 치료제 개발
Improvement of postnatal neovascularization by human embryonic stem cell-derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation. 2007.
A comparison of human cord blood- and embryonic stem cell-derived endothelial progenitor cells in the treatment of chronic wounds. Biomaterials. 2013.
Repair of Ischemic Injury by Pluripotent Stem Cell Based Cell Therapy without Teratoma through Selective Photosensitivity. Stem Cell Reports. 2015.
Functional equivalency in human somatic cell nuclear transfer - derived endothelial cells. Stem Cells. 2019.
Predicting in vivo therapeutic efficacy of bioorthogonally labeled endothelial progenitor cells in hind limb ischemia models via non-invasive fluorescence molecular tomography.
Biomaterials. 2021.
[주요 연구 분야 5] 심장 질환 세포 치료제 개발
The use of aggregates of purified cardiomyocytes derived from human ESCs for functional engraftment after myocardial infarction. Biomaterials. 2013
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction. Nat Commun. 2019.
Effect and application of cryopreserved 3D microcardiac spheroids in myocardial infarction therapy. Clin. Transl. Med. 2022.
Enhancement strategy for effective vascular regeneration through dual stem cell approach following myocardial infarction. Exp. Mol. Med. 2022
[주요 연구 분야 6] 면역인간화 마우스를 이용한 전임상 연구
[주요 연구 분야 7] 심근 세포를 이용한 독성 평가 연구
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes. Antiviral Res. 2020.
A machine learning platform for genotype-specific cardiotoxicity risk prediction using patient-derived iPSC-CMs. J. Adv. Res. 2025. 한빛사 선정 논문 - 박윤귀
